The body's immune system responds defensively to the presence of various substances from the environment. However, it may become sensitised to one of these antigens and over react. The normal protective response can get out of hand. The chemical consequences of this natural function gone awry may become an even larger problem. Histamine output increases and this may create many of the classic symptoms of an allergic reaction. Additionally, stress may leave the body open to an allergic reaction when the adrenal glands must respond more often. This can lead to a depletion of vital chemical defences.

G.H.3 may moderate these problems in several ways: (1) Researchers Ghali, Cohen and Aslan assert that G.H.3 is an anti-histamic (44) (2) Bucci has demonstrated that it moderates the adrenal response (45). (3) Acetylcholine is a counterpart of adrenaline. Since DEAE is a precursor to acetylcholine , it may promote a parasympathetic response during times of stress. (46)