Osteoporosis is primarily caused by a breakdown of bone structure and a loss of calcified tissue. It generally advances with age and therefore usually is identified with geriatric patients. However NASA physicians reported that space travellers in the weightless condition showed an alarming advance of osteoporosis.

G.H.3 treated patients have shown a significant reduction in osteoporosis. Results have been reported both in preventing and reversing it (61) G.H.3 apparently encourages the body to retain calcium. (62) Further, researchers report that over a period of several years remineralization of the whole skeleton can occur. A general thickening of the bones has been noted in patients treated with G.H.3 as well. (63) G.H.3 may improve osteoporosis by its stimulation of the estrogens and androgens as previously documented. These two hormones currently are used as treatments for the condition.