Dr Bernard Wagner of Columbia University conducted studies on this subject. He gave subjects more than 60 times the normal equivalent dosage of G.H.3 for more than four months. He determined that there is no build up of procaine in the cells. In this sense, the procaine acts no differently than other water soluble B-vitamins. Dr Wagner and most other investigations agree that G.H.3 acts on sites in the body in a benign fashion. It dose not damage tissues or alter the basic structure of the organism.