Since it is a nutrient, the exact improvements are not predictable for any one person. It works at a cellular level and therefore the action is general rather than specific. The changes arising from G.H.3 are usually subtle. Individuals used to the dramatic effects of synthetic drugs may not notice any difference day to day. In assessing the benefits, experience shows that it is preferable to look back over several months. Changes in physical and mental status then can be evaluated.

Some users of the product report no benefits of any kind. This may be due to a lack of physical problems to begin with. In this case the nutrient qualities can be regarded as a prophylactic measure at best. Some users simply do not absorb or utilise the ingredients to the extent that health benefits can be realised.